Syn-HL12 High-load nucleic acid synthesizer

The Syn-HL12 high-load nucleic acid synthesizer is mainly used for the synthesis of DNA, RNA, special monomers (LNA, dU, dl), and thiomodified nucleic acids. It is suitable for clinical research, pharmaceutical development, and the synthesis of molecular diagnostic probes, and is specially designed for laboratory scientific research and process development. This instrument supports robust and scalable oligonucleotide synthesis processes, covering large-scale nucleic acid synthesis up to 12mmol.

Syn-HL12 adopts a high-precision constant-flow pump drive system, compatible with the chemical reagents used in nucleic acid synthesis. It uses large-scale laminar flow fixed-bed reaction technology, combining efficient cyclic reaction control with new synthesis process technology and modular dynamic feedback operation software. It has the advantages of low reagent consumption, less reagent residue, and high degree of automation. The solid-phase synthesis column, which is equipped with our company's independent intellectual property technology, effectively and stably ensures a coupling efficiency of over 99% and a crude product synthesis purity of over 75%, efficiently assisting laboratory clinical drug screening research and production process development. Moreover, the synthesis process has a high degree of linear amplification adaptability. This ensures the quality stability, time efficiency stability, cost-benefit stability, etc. from the laboratory research to the small-scale trial stage. 

Features of Syn-HL12

● High precision: Equipped with a 316L stainless steel constant flow pump, the flow error is ±1ml, and it can withstand organic reagents.

● High efficiency: Each cycle takes as little as 20 minutes. The large system laminar flow fixed synthesis column ensures thorough reagent mixing and uniform reaction.

● Multi-bottle position: Up to 18 monomers, covering various modified monomers;

● Low loss: The flow path is switched by rotating the switching valve, effectively controlling the internal dead volume, resulting in low reagent loss.

● High-efficiency reaction: The circulating pump is set up separately to reduce the risk of contamination in the reagent flow path.

● Intelligent interaction: The software interface is flexible to operate and highly automated.

● Online monitoring: Online monitoring of UV, conductivity, pH, pressure and flow to ensure the safe and high-quality progress of synthesis.

● Compliance: Complies with the relevant regulations of the FDA and USP.

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